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  string(9239) "北京大學(xué)第三醫(yī)院血管穩(wěn)態(tài)與重構(gòu)全國重點(diǎn)實(shí)驗(yàn)室xhua@bjmu.edu.cn花欣煒，博士，北京大學(xué)第三醫(yī)院研究員，博士生導(dǎo)師, 血管穩(wěn)態(tài)與重構(gòu)全國重點(diǎn)實(shí)驗(yàn)PI。先后分別于美國埃默里大學(xué)、美國華盛頓大學(xué)獲流行病學(xué)碩士與博士學(xué)位，并于哈佛大學(xué)醫(yī)學(xué)院/麻省總醫(yī)院完成博士后研究。于2022年回國就職于北京大學(xué)第三醫(yī)院心血管內(nèi)科，先后入選國家級海外高層次人才計劃青年項(xiàng)目、北京市科技新星，主持國自然、北京市自然重點(diǎn)專題項(xiàng)目子課題等縱向科研項(xiàng)目。主要研究方向包括利用多組學(xué)技術(shù)和分子流行病學(xué)方法探究外環(huán)境因子與分子表征及其交互作用在心血管疾病發(fā)生和發(fā)展中的作用、利用多維度健康大數(shù)據(jù)（多維度臨床數(shù)據(jù)、多組學(xué)數(shù)據(jù)、以及影像學(xué)數(shù)據(jù)）和人工智能方法輔助心血管疾病的早期診斷和精準(zhǔn)治療。至今以第一作者或者通訊作者（含共同）在J Clinical Oncology、Gastroenterology、Clinical Gastroenterology and Hepatology、Int J Cancer等國際知名學(xué)術(shù)期刊上發(fā)表論文20余篇。教育經(jīng)歷:	2016-2020	博士學(xué)位，美國華盛頓大學(xué)，流行病2010-2012	公共衛(wèi)生碩士，美國埃默里大學(xué)，流行病2006-2010	工科學(xué)士，華南理工大學(xué)，生物工程科研工作經(jīng)歷：2022/04至今	研究員，北京大學(xué)第三醫(yī)院2020/10 -2021/12	博士后，美國麻省總醫(yī)院/哈佛大學(xué)醫(yī)學(xué)院2014/09 -2020/10	助理研究員, 美國華盛頓大學(xué)/ Fred Hutchinson Cancer Research Center研究方向o	搭建心血管疾病的專病前瞻性隊(duì)列（心血管代謝、心力衰竭等）以及大規(guī)模生物樣本庫，整合電子病歷數(shù)據(jù)（EMR）與分子表征用于開發(fā)射血分?jǐn)?shù)保留心衰患者的診斷、分型和風(fēng)險評估工具，以指導(dǎo)個體化干預(yù)。o	研究心血管疾病的環(huán)境因素（如生物標(biāo)志物，生活方式）、遺傳因素及其交互作用對心血管疾病患病風(fēng)險的影響。o	利用多組學(xué)，如代謝組學(xué)、蛋白組、腸道微生物組，探討心血管代謝性疾病的發(fā)病機(jī)制，尋找新的生物靶點(diǎn)和干預(yù)途徑，結(jié)合多維度臨床數(shù)據(jù)、以及醫(yī)學(xué)影像資料，利用人工智能方法輔助心血管疾病的早期鑒別診斷和精準(zhǔn)治療。Xinwei Hua, PhD, MPHInvestigator/Assistant Professor of EpidemiologyDepartment of CardiologyPeking University Third HospitalPeking University Health Science CenterNational Key Laboratory of Vascular and Reconstructive Diseasesxhua@bjmu.edu.cnDr. Xinwei Hua, a molecular and cardiovascular epidemiologist, focuses on studying the molecular and clinical epidemiology of cardiometabolic diseases. By integrating electronic medical record (EMR) data with molecular profiles, her research involves the identification of novel therapeutical and gut-microbial targets for cardiometabolic disease prevention and treatment, and the development of diagnostic, phenotyping and risk assessment tools for individualized treatment for patients with heart failure with preserved ejection fraction.Education	PhD, Epidemiology, University of Washington, 2016-2020MPH, Epidemiology, Emory University, 2010-2012BE, Bioengineering, South China University of Technology, 2006-2010Research Experiences2022/04 to Current	Assistant professor, Peking University Third Hospital2020/10 -2021/12	Postdoctoral research fellow, Mass General Hospital/ Havard Medical School2014/09 -2020/10	Research associate, Fred Hutchinson Cancer Research CenterResearch interestso	Drug, gut microbiome and cardiometabolic disease (CMD)o	Molecular profiling, phenotyping of heart failure with preserved ejection fractiono	Diagnostic, phenotyping and risk assessment tools for CMDPublications1.	Hua X#*, Ungaro RC#*, Petrick LM, Chan AT, Porter CK, Khalili H (2023), Inflammatory Bowel Disease is Associated with Prediagnostic Perturbances in Metabolic Pathways, Gastroenterology, 164.1: 147-150. [IF=29.4, JCR Q1]2.	Zhou Q, Yang J, Wang W, Shao C, Hua X*, Tang YD* (2023). The Impact of the Stress Hyperglycemia Ratio on Mortality and Rehospitalization Rate in Patients with Acute Decompensated Heart Failure and Diabetes. Cardiovascular Diabetology 22 (1): 189. [IF: 9.3, JCR Q1]3.	Zhou Q, Yang J, Tang H, Guo Z, Dong W, Wang Y, Meng X, Zhang K, Wang W, Shao C. and Hua X*, Tang YD* (2023). High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction. Cardiovascular Diabetology, 22(1): 263. [IF: 9.3, JCR Q1]4.	Fuller H, Zhu Y, Nicholas J, Chatelaine HA, Drzymalla EM, Sarvestani AK, Julián-Serrano S, Tahir UA, Sinnott-Armstrong N, Raffield LM, Rahnavard A, Hua X, Shutta KH, Darst BF (2023). Metabolomic Epidemiology Offers Insights into Disease Aetiology. Nature Metabolism 5 (10): 1656–72. (IF=20.8, JCR Q1)5.	Joshi AD, Rahnavard A, Kachroo P, Mendez KM, Lawrence W, Julián-Serrano S, Hua X, Fuller H, Sinnott-Armstrong N, Tabung FK, Shutta KH, Raffield LM, Darst BF, COMETS Early Career Scientist Working Group. (2023). An Epidemiological Introduction to Human Metabolomic Investigations. Trends in Endocrinology and Metabolism: TEM 34 (9): 505–25. [IF=10.9, JCR Q1]6.	Hua X, Lopes EW, Burke KE, Ananthakrishnan A, Rtchter J, Lo CH, Lochhead P, Chan AT, Khalili H (2022), Smoking behavior changes after diagnosis of inflammatory bowel disease and risk of all-cause mortality, Journal of Crohn’s and Colitis, 16(7):1030-1038. [IF: 10.02, JCR Q1]7.	Hua X#, Cao Y#, Morgan DM, Miller K, Chin SM, Bellavance D, Khalili H (2022), Longitudinal analysis of the impact of oral contraceptive use on the gut microbiome, Journal of Medical Microbiology, 71(4), 001512. [IF: 3.196, JCR Q4]8.	Huang Y, Hua X*, Labadie JD, Harrison TA, Dai J, Lindstrom S, Lin Y, Berndt SI, Buchanan DD, Campbell PT, Casey G, Gallinger SJ, Gunter MJ, Hoffmeister M, Jenkins MA, Sakoda LC, Schoen RE, Diergaarde B, Slattery MI, White E, Giles GG, Brenner H, Chang-Claude J, Joshi AD, Ma W, Pai RK, Chan AT, Peters U, Newcomb PA* (2022). Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex- and lifestyle factors- specific associations, International Journal of Cancer, 150(9):1447-1454. [IF: 7.316, JCR Q1]9.	Hua X, Kratz M, Malen R, Dai J, Lindstroem S, Zheng Y, Newcomb PA (2021). Associations between post-treatment inflammatory biomarkers and survival among stage II-III colorectal cancer patients, British Journal of Cancer, 125, 806–815. [IF: 9.075, , JCR Q1]10.	Hua X, Dai J, Lindstrom S, Harrison TA, Lin Y, Alberts SR, Alwers E, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Casey G, Chang-Claude J, Gallinger SJ, Giles GG, Goldberg RM, Gunter MJ, Hoffmeister M, Jenkins MA, Joshi AD, Ma W, Milne RL, Murphy N, Pai RK, Sakoda LC, Schoen RE, Shi Q, Slattery MI, Song M, White E, Le Marchand L, Chan AT, Peters U, Newcomb PA (2021). Genetically predicted circulating C-reactive protein and colorectal cancer survival: A Mendelian randomization study, Cancer Epidemiology, Biomarkers, and Prevention, 30 (7): 1349–1358. [IF: 4.09, JCR Q2]11.	Hua X, Newcomb PA, Chubak J, Malen RC, Ziebell R, Kamineni A, Zhu LC, Upton MP, Wurscher MA, Thomas SS, Newman H, Hardikar S, Burnett-Hartman AN (2020). Colorectal serrated polyp molecular characteristics associated with subsequent advanced colorectal neoplasia. Cancer Causes and Control, 31(7):631-640. [IF: 2.53, JCR Q2]12.	Zheng Y, Hua X, Win AK, MacInnis RJ, Gallinger S, Marchand LL, Lindor NM, Baron JA, Hopper JL, Dowty JG, Antoniou AC, Jenkins MA, Newcomb PA (2020). A new comprehensive colorectal cancer risk prediction model incorporating personal characteristics, family history, and environmental factors. Cancer Epidemiology, Biomarkers, and Prevention, 29(3), 549-557. [IF: 4.09, JCR Q2]13.	Penney KL, Banbury BL, Bien S, Harrison TA, Hua X, Phipps AI, Sun W, Song M, Joshi AD, Alberts SR, Allegra CJ, Atkins J, Colangelo LH, George TJ, Goldberg RM, Lucas PC, Nair SG, Shi Q, Sinicrope FA, Wolmark N, Yothers G, Peters U, Newcomb PA, Chan AT (2020). Genetic Variant Associated with Survival of Patients with Stage II-III Colon Cancer. Clinical Gastroenterology and Hepatology. 18(12):2717-2723.e3. [IF: 13.576, JCR Q1]14.	Hua X, Phipps AI, Burnett-Hartman AN, Adams SV, Hardikar S, Cohen SA, Kocarnik JM, Ahnen DJ, Lindor NM, Baron JA, and Newcomb PA (2017), Timing of aspirin and other nonsteroidal anti-inflammatory drug use among patients with colorectal cancer in relation to tumor markers and survival, Journal of Clinical Oncology, 35, 2806-2813. [IF: 50.717, JCR Q1]15.	Kocarnik JM, Hua X, Hardikar S, Robinson J, Lindor NM, Win AK, Hopper JL, Figueiredo JC, Potter JD, Campbell PT, Gallinger S, Cotterchio M, Adams SV, Cohen SA, Phipps AI and Newcomb PA (2017). Long-term weight loss after colorectal cancer diagnoses is associated with lower survival: The Colon Cancer Family Registry, Cancer, 123(23): 4701-4708. [IF: 6.92, JCR Q1]16.	Hua X, Ward, KC, Gillespie, TW, Lipscomb J, Goodman M (2014). Non-small cell lung cancer treatment receipt and survival among African Americans and whites in a rural area, Journal of Community Health, 39(4), 696-705. [IF: 4.371, JCR Q2]"
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