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  string(7886) "研究員，博士生導(dǎo)師北京大學(xué)第三醫(yī)院血管穩(wěn)態(tài)與重構(gòu)全國(guó)重點(diǎn)實(shí)驗(yàn)室yaohuaz@bjmu.edu.cn張耀華，博士，北京大學(xué)第三醫(yī)院研究員，血管穩(wěn)態(tài)與重構(gòu)全國(guó)重點(diǎn)實(shí)驗(yàn)室PI，內(nèi)科學(xué)（心血管?。┐T、博士研究生導(dǎo)師。博士畢業(yè)于中國(guó)醫(yī)學(xué)科學(xué)院&北京協(xié)和醫(yī)學(xué)院，在國(guó)家心血管病中心，心血管疾病國(guó)家重點(diǎn)實(shí)驗(yàn)室完成博士課題研究。先后在美國(guó)休斯頓健康醫(yī)學(xué)中心和MD Anderson癌癥中心從事博士后研究。入選2022年北京市海外高層次人才青年項(xiàng)目，獲得2022年國(guó)家自然科學(xué)基金委海外優(yōu)青項(xiàng)目資助。研究工作主要是基于多組學(xué)研究技術(shù)，探索蛋白翻譯后修飾在心血管病發(fā)病中的作用機(jī)制。開(kāi)發(fā)疾病評(píng)分和分層的生物標(biāo)志物，輔助實(shí)現(xiàn)疾病的精準(zhǔn)診斷，并開(kāi)發(fā)針對(duì)疾病的精準(zhǔn)干預(yù)策略。近五年以第一作者（含共同）和通訊作者在Science、Nature Cell Biology、Circulation、Science Translational Medicine等國(guó)際知名雜志發(fā)表高水平學(xué)術(shù)論文，累計(jì)影響因子超過(guò)200。教育經(jīng)歷:2013-2016理學(xué)博士學(xué)位，北京協(xié)和醫(yī)學(xué)院，生物化學(xué)與分子生物學(xué)2009-2012理學(xué)碩士，山西大學(xué)，生物化學(xué)與分子生物學(xué)2007-2009管理學(xué)學(xué)士，山西農(nóng)業(yè)大學(xué)，信息管理與信息系統(tǒng)2005-2009理學(xué)學(xué)士，山西農(nóng)業(yè)大學(xué)，生物科學(xué)科研工作經(jīng)歷：2023/10至今研究員，北京大學(xué)第三醫(yī)院2022/01-2023/10教授，北京腦重大疾病研究院2017/12 -2021/12博士后，安德森癌癥中心2017/05-2017/12博士后，休斯頓健康醫(yī)學(xué)中心2012/08 -2013/06研究實(shí)習(xí)員，國(guó)家心血管病中心研究方向：o 基于蛋白翻譯后修飾的心力衰竭發(fā)病機(jī)制和診斷方法研究o 冠心病診斷分層生物標(biāo)志物和分子影像探針開(kāi)發(fā)o 蛋白新型翻譯后修飾的研究和心血管疾病新型干預(yù)方式研發(fā)Yaohua Zhang, PhDPrinciple Investigator, ProfessorState Key Laboratory of Vascular Homeostasis and RemodelingDepartment of Cardiology and Institute of Vascular MedicinePeking University Third HospitalPeking University Health Science Centeryaohuaz@bjmu.edu.cnDr. Yaohua Zhang, a professor at Peking University Third Hospital, holds the position of Principal Investigator (PI) for the National Key Laboratory of Vascular Homeostasis and Remodeling. Before this, he conducted postdoctoral research at the University of Texas Health Science Center in Houston and the renowned MD Anderson Cancer Center in the United States. Acknowledged for his exceptional contributions, Dr. Zhang was honored with the 2022 Beijing Overseas High-level Talents Youth Program and received funding from the Science Fund Program for Excellent Young Scientists (Overseas) in the same year. His research endeavors primarily delve into the mechanisms behind post-translational protein modifications in cardiovascular diseases, leveraging multi-omics technology. His ultimate aim is to establish biomarkers for disease scoring and stratification, thereby enhancing the accuracy of diagnosis and precision in intervention strategies. In the past five years, he has led or contributed significantly to numerous highly influential academic publications in esteemed international journals such as Science, Nature Cell Biology, Circulation, and Science Translational Medicine, collectively achieving a cumulative impact factor surpassing 200.EducationPhD, Biochemistry and Molecular Biology, Peking Union Medical College, 2013-2016MS, Biochemistry and Molecular Biology, Shanxi University, 2009-2012Bachelor of Management, Information Management and Information Systems, Shanxi Agricultural University, 2007-2009Bachelor of Science, Biological Sciences, Shanxi Agricultural University, 2005-2009Research Experiences2023/10 to Current Associate professor, Peking University Third Hospital2022/01-2023/10 Professor, Beijing Institute of Brain Diseases2017/12 -2021/12 Postdoctoral research fellow, MD Anderson Cancer Center2017/05 -2017/12 Postdoctoral research fellow, The University of Texas Health Science Center at Houston2012/08-2013/06 Research Assistant, National Center for Cardiovascular DiseasesResearch interestso Research on the pathogenesis and diagnosis of heart failure based on protein post-translational modificationo Development of biomarkers and molecular imaging probes for stratification of coronary heart disease diagnosiso Research on new protein post-translational modifications and development of new intervention methods for cardiovascular disease Drugs, gut microbiome, and cardiometabolic disease (CMD)Publications· Yaohua Zhang*, Zilong Zhao*, Lisa A Huang*, Yuan Liu, Jun Yao, Chengcao Sun, Yajuan Li, Zhao Zhang, Youqiong Ye, Fei Yuan, Tina K Nguyen, Nikhil Reddy Garlapati, Andrew Wu, Sergey D Egranov, Abigail S Caudle, Aysegul A Sahin, Bora Lim, Laura Beretta, George A Calin, Dihua Yu, Mien-Chie Hung, Michael A Curran, Katayoun Rezvani, Boyi Gan, Zhi Tan, Leng Han#, Chunru Lin#, Liuqing Yang#. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab. 2023 Jun 12: S1550-4131(23)00186-9. 第一作者(IF=29.01)· Xu Han, Zihan Yan, Kaiyu Fan, Xueyi Guan, Bohan Hu, Xiang Li, Yunwei Ou, Bing Cui, Lingxuan An, Yaohua Zhang#, Jian Gong#. The combined signatures of telomere and immune cell landscape provide a prognostic and therapeutic biomarker in glioma. Front Immunol. 2023 Aug 17:14:1220100. 共同通訊作者 (IF=7.3)· Yuru Zong, Xuliang Wang, Bing Cui, Xiaowei Xiong, Andrew Wu, Chunru Lin, Yaohua Zhang. Decoding the Regulatory Roles of Non-coding RNAs in Cellular Metabolism and Disease. Molecular Therapy. 2023 Apr 26; S1525-0016(23)00210-1. 通訊作者（IF=12.910） · Yaohua Zhang*#, Chengcao Sun*, Yajuan Li*, Juan Qin*, Kaushik Amancherla, Ying Jing, Qingsong Hu, Ke Liang, Zhao Zhang, Youqiong Ye, Lisa A. Huang, Tina K. Nguyen, Sergey D. Egranov, Joe-Elie Salem, Douglas B. Johnson, Michael A. Curran, Dihua Yu, Leng Han, Radbod Darabi, Liuqing Yang#, Javid J. Moslehi#, Chunru Lin#. Hormonal Therapies Upregulate MANF and Overcome FemaleSusceptibility to Immune Checkpoint-Inhibitor (ICI)-Myocarditis. Sci Transl Med. 2022 Nov 2;14(669): eabo1981. (第一兼通訊作者) IF=19.319.  · Congxia Bai*, Ming Su*, Yaohua Zhang*, Yahui Lin*, Yingying Sun, Li Song, Ning Xiao, Haochen Xu, Hongyan Wen, Meng Zhang, Jiedan Ping, Jing Liu, Rutai Hui, Hao Li#, Jingzhou Chen#. Oviductal Glycoprotein 1Promotes Hypertension by Inducing Vascular Remodeling Through an Interaction with MYH9. Circulation. 2022 Sep 29: 101-161. IF=39.918. (共同第一作者) · Yaohua Zhang, Yajuan Li, Qingsong Hu et al. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol. 22,1332-1345 (2020). (第一作者) IF=28.213. · Yajuan Li*, Zhi Tan*, Yaohua Zhang* et al. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science. 2021;373(6555):662-673. (共同第一作者) IF=63.714.· Yajuan Li*, Yaohua Zhang*, Qingsong Hu et al. Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects. Genome Med. 2021 Aug 28;13(1):137. (共同第一作者) IF=15.266.· Qingsong Hu, Youqiong Ye, Li-Chuan Chan, Yaohua Zhang et al. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 20, 835-851 (2019). IF=31.25.· Ming-Ze Yao, Yao-Hua Zhang, Wen-Liang Lu, Miao-Qing Hu, Wei Wang, Ai-Hua Liang*. Phytases: Crystal Structures, Protein Engineering and Potential Biotechnological Applications. Journal of Applied Microbiology. 2012,112(1):1-14.· Mingze Yao, Wenliang Lu, Yaohua Zhang, Ai-hua Liang*, Isolation and identification of two phytase-producing strains from soybean rhizosphere soil and cloning of neutral phytase gene. Food Science. 2012, 07(16)."
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