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  string(8265) "1.職稱 教授2.學(xué)歷 博士3.聯(lián)系電話 86-28-85502290;4.電子郵箱 hsiaocchan@cuhk.edu.hk5.研究方向上皮細(xì)胞生物學(xué)，生殖生理學(xué)6.簡(jiǎn)歷:四川大學(xué)－香港中文大學(xué)生殖醫(yī)學(xué)聯(lián)合實(shí)驗(yàn)室主任,香港中文大學(xué)醫(yī)學(xué)院李嘉誠(chéng)生理學(xué)講座教授，博士生導(dǎo)師。國(guó)家自然科學(xué)獎(jiǎng)（二等，2008），全國(guó)婦幼健康科學(xué)技術(shù)獎(jiǎng)（科學(xué)成果獎(jiǎng)，一等，2015），多次獲上海、浙江等省市科學(xué)技術(shù)獎(jiǎng)。于1999年建立了中國(guó)首個(gè)上皮細(xì)胞生物學(xué)研究中心，長(zhǎng)期以來致力于上皮細(xì)胞生物學(xué)和生殖生物學(xué)的研究，并推動(dòng)相關(guān)領(lǐng)域在中國(guó)的發(fā)展，取得了一系列國(guó)際領(lǐng)先的成果，先后在Science，Nature Cell Biology，Nature Medicine, Lancet，PNAS等高影響因子雜志發(fā)表論文近200余篇,累積被引用次數(shù)近3000次。她同時(shí)擔(dān)任《Physiology》，《Journal of PhysiologicalSciences》，《Cell Biology International》，《中國(guó)科學(xué)》，《生殖與發(fā)育生物學(xué)》，《生殖與避孕》等多個(gè)國(guó)內(nèi)、國(guó)際科學(xué)期刊的編委；曾擔(dān)任世界衛(wèi)生組織WHO，美國(guó)國(guó)家科學(xué)基金會(huì)，英國(guó)Welcome Trust以及中國(guó)，德國(guó)，意大利。以色列和奧地利等多個(gè)國(guó)家基金組織的課題評(píng)審員。先后領(lǐng)導(dǎo)或參與包括科技部973，國(guó)家自然科學(xué)基金及香港、國(guó)際等20多個(gè)重大科研項(xiàng)目。在上皮細(xì)胞生物學(xué)和生殖生物學(xué)相關(guān)領(lǐng)域具有深厚的學(xué)術(shù)背景，并享有很高的學(xué)術(shù)聲譽(yù)。2009年創(chuàng)建并主持設(shè)于四川大學(xué)華西第二醫(yī)院的四川大學(xué)—香港中文大學(xué)生殖醫(yī)學(xué)聯(lián)合實(shí)驗(yàn)室，并以此作為推動(dòng)內(nèi)地與香港合作的一個(gè)重要平臺(tái)。Director of Sichuan University - Chinese University of Hong Kong JointLaboratory for Reproductive Medicine， also Li Ka ShingProfessor of Physiology of the Chinese University of Hong Kong.. She has establishedthe first Epithelial Cell Biology Research Center in China in 1999, and hassince then committed to the epithelial cell biology and reproductive biologyresearch and promoted the development of related fields in China, her work haspublished in a series of leading international journals including Science,Nature Cell Biology, Lancet, PNAS published nearly 200 articles, and has beencited near 3000 times. She also served editorial boards in the"Physiology", “Journal of Physiological Sciences”, CellBiology International "," Chinese Science "," Reproductiveand Developmental Biology "," Reproduction and contraception” and other international scientific journals; and served as areviewer for grant applications to the World Health Organization (WHO), theU.S. national Science Foundation, the British Welcome Trust etc. She has led orparticipated in “973”, theNational Natural Science Foundation and the Hong Kong “RGC” over 20 major research projects, thus enjoyed a high academicreputation in the epithelial cell biology and related fields. Created in 2009,the Sichuan University-Chinese University of Hong Kong Joint Laboratory ofReproductive Medicine located in West China Second University Hospital ofSichuan University, and served as an important platform to promote cooperationbetween the Mainland China and Hong Kong.7.代表性論文：（1）J.H.Guo, H. Chen, Y.C. Ruan, X.L. Zhang, X.H. Zhang, K.L. Fok, L.L. Tsang, M.K. Yu,W.Q. Huang, X. Sun, Y.W. Chung, X. Jiang, Y. Sohma, H.C. Chan, Glucose-inducedelectrical activities and insulin secretion in pancreatic islet beta-cells aremodulated by CFTR, Nat Commun 5 (2014) 4420.（2）DiaoR, Fok KL, Chen H, Yu MK, Duan Y, Chung CM, Li Z, Wu H, Li Z, Zhang H, Ji Z,Zhen W, Ng CF, Gui Y, Cai Z, Chan HC. Deficient human β-defensin 1 underliesmale infertility associated with poor sperm motility and genital tractinfection. Sci Transl Med. 2014 Aug 13;6(249):249ra108.（3）G.Guo, X. Sun, C. Chen, S. Wu, P. Huang, Z. Li, M. Dean, Y. Huang, W. Jia, Q.Zhou, A. Tang, Z. Yang, X. Li, P. Song, X. Zhao, R. Ye, S. Zhang, Z. Lin, M.Qi, S. Wan, L. Xie, F. Fan, M.L. Nickerson, X. Zou, X. Hu, L. Xing, Z. Lv, H.Mei, S. Gao, C. Liang, Z. Gao, J. Lu, Y. Yu, C. Liu, L. Li, X. Fang, Z. Jiang,J. Yang, C. Li, X. Zhao, J. Chen, F. Zhang, Y. Lai, Z. Lin, F. Zhou, H. Chen,H.C. Chan, S. Tsang, D. Theodorescu, Y. Li, X. Zhang, J. Wang, H. Yang, Y. Gui,J. Wang, Z. Cai, Whole-genome and whole-exome sequencing of bladder canceridentifies frequent alterations in genes involved in sister chromatid cohesionand segregation, Nat Genet 45(12) (2013) 1459-63.（4）Y.C.Ruan, J.H. Guo, X. Liu, R. Zhang, L.L. Tsang, J.D. Dong, H. Chen, M.K. Yu, X.Jiang, X.H. Zhang, K.L. Fok, Y.W. Chung, H. Huang, W.L. Zhou, H.C. Chan,Activation of the epithelial Na+ channel triggers prostaglandin E(2) releaseand production required for embryo implantation, Nat Med 18(7) (2012) 1112-7.（5）. Y.C. Lu, H. Chen, K.L.Fok, L.L. Tsang, M.K. Yu, X.H. Zhang, J. Chen, X. Jiang, Y.W. Chung, A.C. Ma,A.Y. Leung, H.F. Huang, H.C. Chan, CFTR mediates bicarbonate-dependentactivation of miR-125b in preimplantation embryo development, Cell research22(10) (2012) 1453-66.（6）.C. Xie, X.H. Jiang, J.T. Zhang, T.T. Sun, J.D. Dong, A.J. Sanders, R.Y. Diao,Y. Wang, K.L. Fok, L.L. Tsang, M.K. Yu, X.H. Zhang, Y.W. Chung, L. Ye, M.Y.Zhao, J.H. Guo, Z.J. Xiao, H.Y. Lan, C.F. Ng, K.M. Lau, Z.M. Cai, W.G. Jiang,H.C. Chan, CFTR suppresses tumor progression through miR-193b targetingurokinase plasminogen activator (uPA) in prostate cancer, Oncogene 32(18)(2013) 2282-91, 2291 e1-7（7）. Liu Y, Jiang X, Zhang X,Chen R, Sun T, Fok KL, Dong J, Tsang LL, Yi S, Ruan Y, Guo J, Yu MK, Tian Y,Chung YW, Yang M, Xu W, Chung CM, Li T, Chan HC. (2011) Dedifferentiation-reprogrammed mesenchymal stemcells with improved therapeutic potential. Stem Cells. 29(12):2077-89.（8）.Zhang WK, Wang D, Duan Y, Loy MM, Chan HC, Huang P. (2010) Mechanosensitivegating of CFTR. Nature Cell Biology. 12(7):507-512.（9）. Chan HC, Ruan YC, He Q,Chen MH, Chen H, Xu WM, Chen WY, Xie C, Zhang XH, Zhou Z (2009), The cysticfibrosis transmembrane conductance regulator in reproductive health anddisease. J Physiol. 587(Pt 10):2187-95.（10）. Yin LL, Chung CM, Chen J,Fok KL, Ng CP, Jia RR, Ren X, Zhou J, Zhang T, Zhao XH, Lin M, Zhu H, Zhang XH,Tsang LL, Bi Y, Zhou Z, Mo F, Wong N, Chung YW, Sha J, Chan HC (2008), Asuppressor of multiple extracellular matrix-degrading proteases and cancerme-x-tastasis. J Cell Mol Med. 13(9B):4034-41.（11）. Xu WM, Shi QX, Chen WY,Zhou CX, Ni Y, Rowlands DK, Yi LG, Zhu H, Ma ZG, Wang XF, Chen ZH, Zhou SC,Dong HS, Zhang XH, Chung YW, Yuan YY, Yang WX, Chan HC. (2007) Cystic fibrosistransmembrane conductance regulator is vital to sperm fertilizing capacity andmale fertility. Proc Natl Acad Sci U S A 104:9816-9821.（12）. Yin X, Ouyang S, Xu W,Zhang X, Fok KL, Wong HY, Zhang J, Qiu X, Miao S, Chan HC, Wang L (2007),YWK-II protein as a novel Go-coupled receptor for Mullerian inhibitingsubstance in cell survival. Journal of Cell Science. 120:1521-8.（13）. Zhou CX, Zhang YL, XiaoLQ, Zheng M, Leung KM, Chan MY, Lo PS, Wong HY, Ho LS, Chung YW and Chan HC.(2004) An epididymis-specific-defensin involved in initiation of spermmaturation. Nature Cell Biology 6:458-464.（14）. Wang XF, Zhou CX, Shi QX,Yuan YY, Yu MK, Ho LS, Ajonuma LC, Lo PS, Lam SY Tsang LL, Chan LN, Zhao WC,Chung YW, and Chan HC. (2003) Involvement of CFTR in uterine bicarbonatesecretion and the fertilizing capacity of sperm. Nature Cell Biology 5:902-906.（15）. Zhu H, Zhu JX, Lo PS,Leung KM, Rowlands DK, Tsang LL, Yu MK, Lam SY Jiang JL, Chan LN, Chung YW,Zhou ZM, Sha JH, Chan HC. (2003) Rescue of defective pancreatic duct secretionin cystic fibrosis cells by suppression of a novel phospholipase C isoform.Lancet 362:2059-2065.（16）. Li P, Chan HC, He B, SoSC, Chung YW, Shang Q, Zhang YD & Zhang YL. (2001) An antimicrobial peptidegene found in the male reproductive system of rats. Science 291: 1783-1785.（17）. Chan HC, Fong SK, So SC,Chung YW and Wong PY (1997), Stimulation of anion secretion bybeta-adrenoceptors in the mouse endometrial epithelium. J Physiol. 501 ( Pt3):517-25.（18）. Chan HC and Nelson DJ(1992), Chloride-dependent cation conductance activated during cellularshrinkage. Science. 257(5070):669-71."
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