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  string(9) "孔光耀"
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  string(7245) "孔光耀，男，生物診療中心科室主任,2011年取得南開大學生物化學與分子生物學博士學位。2011-2016年在美國威斯康星大學麥迪遜分校McArdle Laboratory for Cancer Research實驗室任博士后、副研究員。2016年底全職回國，現(xiàn)任生物診療中心副主任、西安交通大學教授、博士生導師。2016年入選西安交通大學“青年拔尖人才支持計劃”A類。2017年入選西安交大醫(yī)學部首批攀登人才計劃，2019年獲國家優(yōu)秀青年科學基金項目。中國生理學會血液生理委員會委員、中國醫(yī)藥治療管理協(xié)會細胞治療質(zhì)量控制與研究專業(yè)委員會委員、陜西省抗癌協(xié)會理事。西安交通大學學報（醫(yī)學版）編委。,近年來一直致力于白血病領(lǐng)域的研究，利用基因工程小鼠研究Ras誘導的骨髓增殖性腫瘤（包括慢性粒單核細胞白血病和幼年型粒單核細胞白血?。┌l(fā)生發(fā)展的分子機制、疾病動物模型的構(gòu)建及其靶向治療等，并取得了一系列的研究成果。共發(fā)表SCI論文40余篇，其中以第一作者或共同第一作者在The Journal of Clinical Investigation (IF=12.575), Leukemia (IF=12.104), Blood (IF=11.841), Science Advances (Science子刊), Journal of Biological Chemistry (IF=4.258)等雜志發(fā)表學術(shù)論文12篇。,研究領(lǐng)域：,白血病致病機制研究,造血干細胞研究,白血病靶向治療,小鼠動物模型構(gòu)建,臨床前動物模型構(gòu)建,主持項目,國家自然科學基金青年項目 Notch信號通路在幼年型粒單核細胞白血病中細胞自主性和非細胞自主性作用的研究 2017.01-2019.12 18萬 主持,國家自然科學基金面上項目 Runx1在慢性粒單核細胞白血病中的作用及其機制研究 2018.01-2021.12 50萬 主持,國家自然科學基金優(yōu)秀項目 骨髓異常增生/骨髓增殖性腫瘤 2020.01-2022.12 120萬 主持,國家重點研發(fā)計劃課題 跨器官通訊影響病理狀態(tài)下造血穩(wěn)態(tài)的作用和機理 2019.12-2024.11 344萬 課題負責人,代表性論文：,1. Li J, Li R, Jiang W, Sun J, Li J, Guo Y, Zhu K, Zhang C,Kong G#, Li Z#. Splenic serum from portal hypertensive patients enhances liver stem cell proliferation and self-renewal via the IGF-II/ERK signaling pathway. Dig Liver Dis. 2020 (#corresponding author),2. Zhang H, Zhang S, Zhang J, Zhou R, Nie Y, Ren S, Li J, Feng K, Ji F,Kong G#, Li Z#. Improvement of human platelet aggregation post-splenectomy with paraesophagogastric devascularization in chronic hepatitis B patients with cirrhotic hypersplenism. Platelets. 2019 (#corresponding author),3. Zhu K, Li J, Li J, Sun J, Guo Y, Tian H, Li L, Zhang C, Shi M,Kong G#, Li Z#. Ring1 promotes the transformation of hepatic progenitor cells into cancer stem cells through the Wnt/β-catenin signaling pathway. J Cell Biochem. 2019 (#corresponding author),4. Sun J, Guo Y, Bie B, Zhu M, Tian H, Tian J, Li J, Yang Y, Ji F,Kong G#, Li Z#. Silencing of long noncoding RNA HOXD-AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway. J Cell Biochem. 2019 (#corresponding author),5. You X, Wen Z, Chang YI, Ranheim EA, Zhou Y, Zhou L,Kong G#, Zhang J#. Systemic Notch downregulation promotes KrasG12D -induced myeloproliferative neoplasm. Br J Haematol. 2019 (#corresponding author),6.Kong G*#, You X*, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, Yang D, Zhong X, Padron E, Zhou L, Pear WS, Zhang J.#. Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia. 2019 (#corresponding author) (Impact factor=10.02),7. Lu Z*, Hong CC*, Kong G*, Assump??o ALFV#, Ong IM, Bresnick EH, Zhang J, Pan X. Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence. Cell Rep. 22(6):1545-1559. 2018(*equal contribution),8.Li Y, Jiang W, Li ZZ, Zhang C, Huang C, Yang J,Kong GY#, Li ZF#. Repetitive restraint stress changes spleen immune cell subsets through glucocorticoid receptor or β-adrenergic receptor in a stage dependentmanner. Biochem Biophys Res Commun. 2018 (#corresponding author) (Impact factor=2.559),9.Jiang W, Li Y, Sun J, Li L, Li JW, Zhang C, Huang C, Yang J,Kong GY#, Li ZF#.Spleen contributes to restraint stress induced changes in blood leukocytes distribution.Sci Rep. 2017(#corresponding author)(Impact factor=4.122),10.Zhang J*,Kong G*, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J.p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.Blood.2017(*equal contribution)(Impact factor=11.841),11.Kong G, Chang YI, You X, Ranheim EA, Zhou Y, Burd CE, Zhang J. The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent.Leukemia.2016(Impact factor=12.104),12.Kong G*,Chang Y-I*, Damnernsawad A*, You X*, Du J, Ranheim E, Lee W, Ryu M, Zhou Y, Xing Y, Chang Q, Burd C, Zhang J. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis.Leukemia.2016 (*equal contribution)(Impact factor=12.104),13.Johnson, K. D.*,Kong, G*, Gao, X., Chang, Y .-I., Hewitt, K. J., Sanalkumar, R., Sanalkumar, P., Ranheim, R. A., Dewey, C. N., Zhang, J., and Bresnick, E. H. Cis-regulatory Mechanisms Governing Stem and Progenitor Cell Transitions. Science Advances.Science Advances2015 (*equal contribution),14.Kong G,Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J, Chang YI, Du J, Liu Y, Tey SR, Zhang X, Juckett M, Mattison R, Damnernsawad A, Zhang J, Mulloy JC, Zhang J. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.The Journal of Clinical Investigation.2014(Impact factor=12.575),15.Wang J*,Kong G*, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J. NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.Blood.2013 (*equal contribution)(Impact factor=11.841),16. Kong G*, Du J*, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J. Notch1 mutations target Kras G12D CD8+ cells and contribute to their leukemogenic transformation.J Biol Chem.2013 (*equal contribution)(Impact factor=4.258),17. Zhang W*,Kong G*, Zhang J, Wang T, Ye L, Zhang X. MiR-520b inhibits growth of hepatoma cells by targeting cyclin D1 and MEKK2.PLoS ONE, 2012 (*equal contribution)(Impact factor=3.057),18.Kong G,Zhang J, Zhang S, Shan C, Ye L, Zhang X. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model.PLoS ONE.2011(Impact factor=3.057),19.Kong G,Zhang J, Zhang S, Shan C, Ye L, Zhang X. Hepatitis B Virus x protein promotes proliferation of hepatoma cells via upregulation of MEKK2.Acta Pharmacologica Sinica, 2011.(Impact factor=3.166),西安交通大學第二附屬醫(yī)院,生物診斷治療國家地方聯(lián)合工程研究中心,通訊地址:陜西省西安市西五路157號, 710004"
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